What is the reversal drug for benzodiazepines?

Flumazenil is the specific reversal agent used for benzodiazepine overdose. It works as a competitive antagonist at the benzodiazepine binding site on the GABA-A receptor. By binding to these receptors, flumazenil effectively counteracts the effects of benzodiazepines, such as sedation and respiratory depression, thus restoring normal function in individuals who have consumed excessive amounts of these drugs.

This is particularly important in emergency situations where the sedative effects of benzodiazepines can lead to serious complications. The rapid action of flumazenil can facilitate the recovery of consciousness in patients, allowing for close monitoring and further medical treatment. It’s important to note that the other options listed either do not reverse benzodiazepine effects or are used for entirely different purposes. For example, atropine is used for bradycardia; naloxone is an opioid antagonist; and clozapine is an antipsychotic medication, none of which are effective in reversing benzodiazepine effects.