What side effect is caused by ganglionic blockade when using certain NMB?

Ganglionic blockade occurs when the transmission of nerve impulses at autonomic ganglia is inhibited, which can lead to various cardiovascular effects. In the context of neuromuscular blockers (NMBs), this blockade interferes with the normal sympathetic nervous system activity that regulates blood vessel tone and heart rate.

The result of this interference typically includes a drop in vascular resistance due to unopposed parasympathetic activity, leading to vasodilation. Consequently, this vasodilation can cause a reduction in blood pressure, known as hypotension. This side effect is particularly relevant during the administration of certain neuromuscular blockers that affect autonomic ganglia and contribute to this vascular response.

Understanding this mechanism is crucial not only for predicting side effects of medications but also for managing patient care during procedures where neuromuscular blockers are used.