Which medication is known to produce extrapyramidal reactions?

Reglan, which is the brand name for metoclopramide, is known to produce extrapyramidal reactions due to its action as a dopamine antagonist. These reactions can include symptoms such as tremors, rigidity, bradykinesia, and tardive dyskinesia. This is particularly relevant because metoclopramide primarily works on the central nervous system by blocking dopamine receptors, especially in the mesolimbic pathway, which is associated with the control of movement.

While H2 blockers may cause some side effects, they are not typically linked to extrapyramidal symptoms as they primarily work by blocking histamine receptors to reduce gastric acid secretion. Naloxone, an opioid antagonist, is used to reverse opioid overdoses and does not produce extrapyramidal reactions. Similarly, etomidate is a sedative-hypnotic agent used primarily for induction in anesthesia, and it does not have a known association with causing extrapyramidal symptoms. Therefore, metoclopramide is the medication that is primarily recognized for this type of adverse effect.