Which of the following factors does NOT increase nondepolarizing neuromuscular block?

The correct answer indicates that cephalosporins do not increase nondepolarizing neuromuscular block. Nondepolarizing neuromuscular blockers, which are often used in surgical procedures to induce paralysis, can be influenced by several factors that either potentiate or diminish their effects.

Myasthenia Gravis is a neuromuscular disorder characterized by weakness and rapid fatigue of voluntary muscles. This condition is known to increase sensitivity to nondepolarizing agents, which leads to a greater neuromuscular block.

Lithium affects neuromuscular transmission and can enhance the effects of nondepolarizing neuromuscular blockers, leading to an increased block. It may alter neuromuscular transmission and enhance the paralysis produced by these agents.

Hypokalemia, or low potassium levels, can increase the effect of nondepolarizing neuromuscular blockers. Potassium is essential for normal neuromuscular function, and its deficiency can lead to increased sensitivity to these medications.

In contrast, cephalosporins, which are a class of antibiotics, are generally not associated with an increase in neuromuscular block. Their mechanism mainly involves bacterial cell wall synthesis inhibition and does not impact neuromuscular function