Which of the following is a major concern during central line placement procedures?

A major concern during central line placement procedures is the potential for air embolism. This risk arises when air enters the vascular system during the insertion of the central line, which can lead to serious complications. An air embolism can obstruct blood flow and potentially damage vital organs or lead to life-threatening conditions such as a stroke or respiratory distress.

During the procedure, it is crucial to minimize the risk of air entering the bloodstream by maintaining appropriate positioning of the patient, using the correct insertion techniques, and ensuring that devices are properly sealed when accessed. Awareness and precautionary measures must be prioritized to mitigate this risk effectively. While other concerns like pain management and post-operative delirium may also be important in a broader healthcare context, the unique risk associated with air embolism specifically pertains to the technical and physiological aspects of central line placement.